Incidence of adenocarcinoma of esophago-gastric junction (AEG) in China presents an obviously increasing trend. Due to the particular anatomic site, its definition, classification, staging, surgical approach, resection pattern, extent of lymphadenectomy, and neoadjuvant therapy, etc. remain controversial. The goal of this expert consensus is to improve the homogeneity in understanding and practice among Chinese thoracic and gastrointestinal surgeons, and to further standardize surgical treatment of AEG. This consensus was generated based on the best available clinical evidence, the latest global guidelines or consensuses, and the agreement from the Chinese expert panel. The panel composed of 19 thoracic surgeons and 20 gastrointestinal surgeons nationwide. Delphi technique was used to generate agreement rates and revision details. In the fields of aforementioned controversies, the present consensus produced 27 statements on surgical treatment-related recommendations for AEG, as well as 9 issues as investigational surgical concerns. The present consensus consists of 7 parts:(1) definition and classification of AEG; (2) surgical approach; (3) minimally invasive surgery; (4) pattern and extent of resection; (5) combined organ resection; (6) lymph node group and lymphadenectomy standard; and(7) neoadjuvant therapy. Pending issues in this consensus need further high-quality clinical research.