The current situation of pancreatic cancer is that the etiology is not clear and prevention is difficult. The sensitivity and specificity of the auxiliary detection method are low, and early diagnosis is a worldwide problem. The efficacy of existing treatment method is not satisfied and is difficult to break through in a short time. The 5-year overall survival rate is only 7.2%. In face of the current situation of pancreatic cancer, the key solution is to strengthen basic research, explore its etiology and pathogenesis, prevent carcinogenesis and development. Developments of the efficacy of peripheral blood and urine detection technology, imaging diagnosis technology are the critical manners to improve the early diagnosis rate. However, the research on basic and early diagnosis techniques takes a long time and costs a lot, which makes it difficult to achieve result in a short time. Therefore, the problem to be solved urgently is to develop a personalized treatment plan through standardized multi-disciplinary treatment (MDT), optimized combination of existing diagnosis and treatment methods, which may achieve the purpose of improving efficacy. This expert consensus is developed from the first edition, which is based on the diagnosis and treatment status of pancreatic cancer and the dilemma that is difficult to break through in a short time, with reference to the successful diagnosis and treatment experience at home and abroad, combined with the national condition of our country, repeated deliberation, discussion and revision by many domestic well-known experts. This consensus discusses the meaning and purpose, the main tasks, the necessary objective conditions for carrying out, workflows, precautions, relevant clinical and basic research of MDT, explorations of multi-center MDT mode and internet MDT (eMDT) mode in detail. Through the formulation and publication of this consensus, we hope that it can promote the development of standardized pancreatic cancer MDT and improve the therapeutic efficacy of pancreatic cancer in China, summarize successful experience and promote international exchanges, strengthen personnel training and echelon construction, formulate relevant policy and promote the development of MDT in the whole country. This is an expert consensus on the MDT model developed in China, which is not only applied to pancreatic cancer, but also can be used as a reference for other tumors.