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SEOM Clinical Guidelines for Cervical Cancer (2019)

原文:2020年 发布于 Clinical & Translational Oncology 22卷 第2期 270-278 浏览量:389 原文链接

作者: Spanish Society of Medical Oncology

归属分类: 所属人体系统: 生殖 | 分类: 子宫肿瘤

关键词: Cervical Cancer Staging Treatment.

指南简介

Cervical cancer (CC) is the fourth most common cancer in women worldwide, strongly linked to high-risk human papilloma virus infection. In high-income countries, the screening programs have dramatically decreased the incidence of CC; however, the lack of accessibility to them in developing countries makes CC an important cause of mortality. Clinical stage is the most relevant prognostic factor in CC. The new FIGO staging system published in 2018 is more accurate than the previous one since it takes into account the lymph node status. In early stages, the primary treatment is surgery-with some concerns recently raised regarding minimally invasive surgery because it might decrease survival-or radiotherapy, whereas concomitant chemo-radiotherapy is the conventional approach in locally advanced stages. For recurrent or metastatic CC, the combination of chemotherapy plus bevacizumab is the preferred therapy. Immunotherapy approach based on checkpoint inhibitors is evolving as the election therapy following failure to platinum therapy.