Based on the update of the S3-Guideline Early Detection, Diagnosis, Treatment and Follow-up Care of Breast Cancer (Version 4.0, December 2017, AWMF registry number 032-045OL, www.leitlinienprogramm-onkologie.de ), evolving topics and relevant changes to the former 2012 version concerning early detection and mammography screening are presented. The outline and figures follow the original text.