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Interdisciplinary S2k Guidelines on the Diagnosis and Treatment of Vaginal Carcinoma and Its Precursors-recommendations on Surgical Pathology for Histopathological Workup, Diagnostics, and Reporting

原文:2021年 发布于 Pathologe 42卷 第1期 116-124 浏览量:362 原文链接


归属分类: 所属人体系统: 生殖 | 分类: 阴道肿瘤

关键词: Cancer Diagnostic Guidelines Histopathology Prognosis Staging Treatment VaIN Vagina WHO Workup


Primary vaginal carcinoma is rare. There are two pathogenetic pathways, one associated with HPV high-risk infection and another one with inactivation of p53. Vaginal Paget's disease is rare and mostly associated with vulvar disease or represents intravaginal spread of associated locoregional cancer. Diagnostic vaginal biopsies should be examined by step sections on H&E. Sentinel lymph nodes should be processed completely using ultrastaging. Morphology-based prognostic factors with good clinical evidence are tumour stage and lymph node status. Molecular markers are not currently relevant for treatment decision and prognosis.