Fatigue is rarely an isolated symptom and most commonly occurs with other symptoms and signs, such as pain, emotional distress, anemia, and sleep disturbances, in symptom clusters. Therefore, patients should be screened for multiple symptoms and signs that may vary according to diagnosis, treatment, and stage of disease. • Fatigue is a subjective experience that should be systematically assessed using patient self-reports and other sources of data.• Fatigue should be screened, assessed, and managed according to clinical practice guidelines.• All patients should be screened using age-appropriate measures for fatigue at their initial visit, at regular intervals during and following cancer treatment, and as clinically indicated.• Fatigue should be recognized, evaluated, monitored, documented, and treated promptly for all age groups, at all stages of disease, prior to, during, and following treatment.• Patients and family/caregiver(s) should be informed that management of fatigue is an integral part of total health care and that fatigue can persist following treatment.• Implementation of guidelines for fatigue evaluation and management is best accomplished by interdisciplinary teams who are able to tailor interventions to the needs of the individual patient. Consider referral to an appropriate specialist or supportive care provider (eg, survivorship, palliative care, integrative oncology, psychology, psychiatry, physical therapy).• Educational and training programs should be implemented to ensure that health care professionals have knowledge and skills in the assessment and management of fatigue.• Cancer-related fatigue should be included in clinical health outcome studies as an independent variable and potential moderator of outcome.• Quality of fatigue management should be included in institutional continuous quality improvement projects.• Medical care contracts should include reimbursement for the management of fatigue.• Disability insurance should include coverage for the continuing effects of fatigue.• Consider referral to rehabilitation as indicated: physical therapy, occupational therapy, and physical medicine from diagnosis to end of life