Extraordinary advances in cancer diagnosis and treatment have led to > 16.5 million people living with and beyond cancer in the United States.1 Modern multimodality treatment, including surgery, radiotherapy, systemic chemotherapy, and targeted therapy, can result in short-term and long-term adverse physical and/or psychosocial effects. Although prevalence rates of sexual difficulties associated with cancer and its treatment vary with primary diagnosis, treatment modality, methods of assessment, and type of sexual difficulty,2 estimates are reported to range from 40% to 100%.3,4 Sexual difficulties include disorders of sexual desire and sexual response that are influenced by the biologic, physiologic, and psychological challenges that cancer and its treatments present.