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Penile Cancer: a Brazilian Consensus Statement for Low- and Middle-income Countries

原文:2020年 发布于 Journal of Cancer Research and Clinical Oncology 146卷 第12期 3281-3296 浏览量:494 原文链接


归属分类: 所属人体系统: 生殖 | 分类: 阴茎癌

关键词: Cancer Consensus HPV Cancer-related Penile Cancer Urologic Malignancy


Purpose: Penile cancer is highly prevalent in low- and middle-income countries, with significant morbidity and mortality rates. The first Brazilian consensus provides support to improve penile cancer patients' outcomes, based on expert's opinion and evidence from medical literature.

Methods: Fifty-one Brazilian experts (clinical oncologists, radiation oncologists, urologists, and pathologists) assembled and voted 104 multiple-choice questions, confronted the results with the literature, and ranked the levels of evidence.

Results: Healthcare professionals need to deliver more effective communication about the risk factors for penile cancer. Staging and follow-up of patients include physical examination, computed tomography, and magnetic resonance imaging. Close monitoring is crucial, because most recurrences occur in the first 2-5 years. Lymph-node involvement is the most important predictive factor for survival, and management depends on the location (inguinal or pelvic) and the number of lymph nodes involved. Conservative treatment may be helpful in selected patients without compromising oncological outcomes; however, surgery yields the lowest rate of local recurrence.

Conclusion: This consensus provides an essential decision-making orientation regarding this challenging disease.